QUO is not a valid scrabble word, which is a shame as it would score 12 points.
However it is a good set of letters to use to place some excellent words, which score even more highly.

Words Starting With Quo
Word | Score |
Quoad | 15 |
Quod | 14 |
Quodded | 19 |
Quodding | 20 |
Quodlibet | 21 |
Quodlibetarian | 26 |
Quodlibetarians | 27 |
Quodlibetic | 25 |
Quodlibetical | 27 |
Quodlibetically | 32 |
Quodlibets | 22 |
Quodlin | 17 |
Quodlins | 18 |
Quods | 15 |
Quohog | 19 |
Quohogs | 20 |
Quoif | 17 |
Quoifed | 20 |
Quoifing | 21 |
Quoifs | 18 |
Quoin | 14 |
Quoined | 17 |
Quoining | 18 |
Quoins | 15 |
Quoist | 15 |
Quoists | 16 |
Quoit | 14 |
Quoited | 17 |
Quoiter | 16 |
Quoiters | 17 |
Quoiting | 18 |
Quoits | 15 |
Quokka | 23 |
Quokkas | 24 |
Quoll | 14 |
Quolls | 15 |
Quomodo | 19 |
Quomodos | 20 |
Quondam | 19 |
Quonk | 18 |
Quonked | 21 |
Quonking | 22 |
Quonks | 19 |
Quooke | 19 |
Quop | 15 |
Quopped | 21 |
Quopping | 22 |
Quops | 16 |
Quorate | 16 |
Quorum | 17 |
Quorums | 18 |
Quota | 14 |
Quotabilities | 24 |
Quotability | 25 |
Quotable | 19 |
Quotableness | 23 |
Quotablenesses | 25 |
Quotably | 22 |
Quotas | 15 |
Quotation | 18 |
Quotations | 19 |
Quotatious | 19 |
Quotative | 21 |
Quotatives | 22 |
Quote | 14 |
Quoted | 16 |
Quoter | 15 |
Quoters | 16 |
Quotes | 15 |
Quoteworthy | 29 |
Quoth | 17 |
Quotha | 18 |
Quotidian | 19 |
Quotidians | 20 |
Quotient | 17 |
Quotients | 18 |
Quoting | 17 |
Quotition | 18 |
Quotitions | 19 |
Quotum | 17 |
Quotums | 18 |
Words Containing Quo
And quo is in many high scoring words too:
Word | Score |
Aequorin | 17 |
Aequorins | 18 |
Aliquot | 16 |
Aliquots | 17 |
Beliquor | 19 |
Beliquored | 22 |
Beliquoring | 23 |
Beliquors | 20 |
Chechaquo | 28 |
Chechaquos | 29 |
Dacquoise | 21 |
Dacquoises | 22 |
Grandiloquous | 24 |
Inquorate | 18 |
Liquor | 15 |
Liquored | 18 |
Liquorice | 20 |
Liquorices | 21 |
Liquoring | 19 |
Liquorish | 21 |
Liquorishly | 26 |
Liquorishness | 25 |
Liquorishnesses | 27 |
Liquors | 16 |
Metasequoia | 22 |
Metasequoias | 23 |
Misquotation | 23 |
Misquotations | 24 |
Misquote | 19 |
Misquoted | 21 |
Misquoter | 20 |
Misquoters | 21 |
Misquotes | 20 |
Misquoting | 22 |
Multiloquous | 23 |
Narquois | 17 |
Nonquota | 17 |
Outquote | 17 |
Outquoted | 19 |
Outquotes | 18 |
Outquoting | 20 |
Requote | 16 |
Requoted | 18 |
Requotes | 17 |
Requoting | 19 |
Requoyle | 20 |
Requoyled | 22 |
Requoyles | 21 |
Requoyling | 23 |
Sequoia | 16 |
Sequoias | 17 |
Siliquose | 18 |
Siliquous | 18 |
Somniloquous | 23 |
Squoosh | 19 |
Squooshed | 22 |
Squooshes | 21 |
Squooshier | 22 |
Squooshiest | 23 |
Squooshing | 23 |
Squooshy | 23 |
Turquois | 17 |
Turquoise | 18 |
Turquoises | 19 |
Underquote | 20 |
Underquoted | 22 |
Underquotes | 21 |
Underquoting | 23 |
Unliquored | 20 |
Unquotable | 21 |
Unquote | 16 |
Unquoted | 18 |
Unquotes | 17 |
Unquoting | 19 |
Ventriloquous | 25 |
Conclusion: So Is QUO A Legal Scrabble Word?
No Quo isn’t a legal scrabble word.
But it is a good collection of letters to potentially score highly with other words containing quo.