QUO is not a valid scrabble word, which is a shame as it would score 12 points.
However it is a good set of letters to use to place some excellent words, which score even more highly.

Words Starting With Quo
| Word | Score |
| Quoad | 15 |
| Quod | 14 |
| Quodded | 19 |
| Quodding | 20 |
| Quodlibet | 21 |
| Quodlibetarian | 26 |
| Quodlibetarians | 27 |
| Quodlibetic | 25 |
| Quodlibetical | 27 |
| Quodlibetically | 32 |
| Quodlibets | 22 |
| Quodlin | 17 |
| Quodlins | 18 |
| Quods | 15 |
| Quohog | 19 |
| Quohogs | 20 |
| Quoif | 17 |
| Quoifed | 20 |
| Quoifing | 21 |
| Quoifs | 18 |
| Quoin | 14 |
| Quoined | 17 |
| Quoining | 18 |
| Quoins | 15 |
| Quoist | 15 |
| Quoists | 16 |
| Quoit | 14 |
| Quoited | 17 |
| Quoiter | 16 |
| Quoiters | 17 |
| Quoiting | 18 |
| Quoits | 15 |
| Quokka | 23 |
| Quokkas | 24 |
| Quoll | 14 |
| Quolls | 15 |
| Quomodo | 19 |
| Quomodos | 20 |
| Quondam | 19 |
| Quonk | 18 |
| Quonked | 21 |
| Quonking | 22 |
| Quonks | 19 |
| Quooke | 19 |
| Quop | 15 |
| Quopped | 21 |
| Quopping | 22 |
| Quops | 16 |
| Quorate | 16 |
| Quorum | 17 |
| Quorums | 18 |
| Quota | 14 |
| Quotabilities | 24 |
| Quotability | 25 |
| Quotable | 19 |
| Quotableness | 23 |
| Quotablenesses | 25 |
| Quotably | 22 |
| Quotas | 15 |
| Quotation | 18 |
| Quotations | 19 |
| Quotatious | 19 |
| Quotative | 21 |
| Quotatives | 22 |
| Quote | 14 |
| Quoted | 16 |
| Quoter | 15 |
| Quoters | 16 |
| Quotes | 15 |
| Quoteworthy | 29 |
| Quoth | 17 |
| Quotha | 18 |
| Quotidian | 19 |
| Quotidians | 20 |
| Quotient | 17 |
| Quotients | 18 |
| Quoting | 17 |
| Quotition | 18 |
| Quotitions | 19 |
| Quotum | 17 |
| Quotums | 18 |
Words Containing Quo
And quo is in many high scoring words too:
| Word | Score |
| Aequorin | 17 |
| Aequorins | 18 |
| Aliquot | 16 |
| Aliquots | 17 |
| Beliquor | 19 |
| Beliquored | 22 |
| Beliquoring | 23 |
| Beliquors | 20 |
| Chechaquo | 28 |
| Chechaquos | 29 |
| Dacquoise | 21 |
| Dacquoises | 22 |
| Grandiloquous | 24 |
| Inquorate | 18 |
| Liquor | 15 |
| Liquored | 18 |
| Liquorice | 20 |
| Liquorices | 21 |
| Liquoring | 19 |
| Liquorish | 21 |
| Liquorishly | 26 |
| Liquorishness | 25 |
| Liquorishnesses | 27 |
| Liquors | 16 |
| Metasequoia | 22 |
| Metasequoias | 23 |
| Misquotation | 23 |
| Misquotations | 24 |
| Misquote | 19 |
| Misquoted | 21 |
| Misquoter | 20 |
| Misquoters | 21 |
| Misquotes | 20 |
| Misquoting | 22 |
| Multiloquous | 23 |
| Narquois | 17 |
| Nonquota | 17 |
| Outquote | 17 |
| Outquoted | 19 |
| Outquotes | 18 |
| Outquoting | 20 |
| Requote | 16 |
| Requoted | 18 |
| Requotes | 17 |
| Requoting | 19 |
| Requoyle | 20 |
| Requoyled | 22 |
| Requoyles | 21 |
| Requoyling | 23 |
| Sequoia | 16 |
| Sequoias | 17 |
| Siliquose | 18 |
| Siliquous | 18 |
| Somniloquous | 23 |
| Squoosh | 19 |
| Squooshed | 22 |
| Squooshes | 21 |
| Squooshier | 22 |
| Squooshiest | 23 |
| Squooshing | 23 |
| Squooshy | 23 |
| Turquois | 17 |
| Turquoise | 18 |
| Turquoises | 19 |
| Underquote | 20 |
| Underquoted | 22 |
| Underquotes | 21 |
| Underquoting | 23 |
| Unliquored | 20 |
| Unquotable | 21 |
| Unquote | 16 |
| Unquoted | 18 |
| Unquotes | 17 |
| Unquoting | 19 |
| Ventriloquous | 25 |
Conclusion: So Is QUO A Legal Scrabble Word?
No Quo isn’t a legal scrabble word.
But it is a good collection of letters to potentially score highly with other words containing quo.